PharmGKB summary
نویسندگان
چکیده
منابع مشابه
PharmGKB summary: tramadol pathway.
Departments of Genetics, Bioengineering, Stanford University, Stanford, California, USA, Department of Anaesthesiology and Pain Medicine, Inselspital, Department of Clinical Research, University of Bern, Bern, Switzerland and Institute of Clinical Pharmacology, University Medical Center, Göttingen, Germany Correspondence to Teri E. Klein, PhD, Department of Genetics, Stanford University Medical...
متن کاملPharmGKB summary: phenytoin pathway.
Phenytoin is one of the most widely prescribed antiepileptic drugs (AEDs) in the USA (approximately 52% of AED prescriptions compared with 19% for valproic acid, 11% carbamazepine, and 7% phenobarbital) [1]. It has a narrow therapeutic range and wide interindividual variability in clearance and, as such, therapeutic drug monitoring is often necessary. Adverse effects of phenytoin range from min...
متن کاملPharmGKB summary: cyclosporine and tacrolimus pathways.
Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone immunosuppressive agents administered to solid organ transplant recipients to prevent and treat allograft rejection. The discovery of cyclosporine in the 1970s, and its entry into the collection of immunosuppressants in the early 1980s, was a major breakthrough in medicine. Cyclosporine was the most successful antirejectio...
متن کاملPharmGKB submission update: IX. ADRB1 gene summary.
Gene Common Name: 1 Adrenergic Receptor ( 1AR) Introductory Information: The 1-adrenergic receptor ( 1AR) is a G-protein-coupled receptor that was first characterized by its pharmacological specificity. The gene for this receptor (ADRB1) was cloned in 1987 from a placental cDNA library and subsequently mapped to chromosome 10q24-q26 (10q25.3). The intronless gene consists of 1,714 bp and codes ...
متن کاملPharmGKB summary: very important pharmacogene information for RYR1.
CYP1A2 is part of the cytochrome P450 (CYP) family of drug-metabolizing enzymes. The CYP1A2 gene is found in a cluster with CYP1A1 and CYP1B1 on chromosome 15 [1]. CYP1A2 and CYP1A1 share a 5′-flanking region of approximately 23 kb, which contains shared regulatory elements, although the genes are positioned back to back and transcription occurs in opposite directions [2]. The CYP1A2 gene spans...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2014
ISSN: 1744-6872
DOI: 10.1097/fpc.0000000000000048